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Neuroprotective and Anti-inflammatory Effects of Medical Cannabis in Parkinson's Disease

Parkinson’s disease is a progressive nervous system disorder that affects movement. It is caused by the degeneration of dopamine-producing neurons in the brain. The disease is characterized by tremors, stiffness, and difficulty with coordination and balance. While there is no cure for Parkinson’s, treatments are available to help manage its symptoms.

Recent research suggests that medical cannabis may be a promising treatment option for individuals with Parkinson’s. Cannabinoids, the active compounds in medical marijuana, have been found to have neuroprotective and anti-inflammatory effects, which may help to alleviate some of the symptoms associated with Parkinson’s disease.

A 2020 study published in the European Journal of Pain found that medicinal cannabis significantly reduced pain and improved the quality of life in patients with Parkinson’s. Another 2020 study published in the Journal of Parkinson’s Disease found that medical marijuana improved motor and non-motor symptoms in patients with Parkinson’s. In this study, patients were able to move around with a greater range of mobility than before medical marijuana use. 

While more research is needed to fully understand the potential benefits and risks of using medical cannabis to treat Parkinson’s disease, these findings are promising. 

Patients need to discuss the potential benefits and risks of using medical cannabis with their healthcare provider before beginning the medical marijuana card certification process.

References

1. Elsohly MA, Radwan MM, Gul W, Chandra S, Galal A. Phytochemistry of Cannabis sativa L. Prog Chem Org Nat Prod. 2017;103:1-36.

2. Kluger B, Triolo P, Jones W, Jankovic J. The Therapeutic Potential of Cannabinoids for Movement Disorders. Mov Disord. 2015;30(3):313-327.

3. Pisani V, Moschella V, Bari M, et al. Medical Cannabis in Parkinson Disease: Real-Life Patients’ Experience. Clin Neuropharmacol. 2018;41(6):250-254.

4. Chagas MH, Eckeli AL, Zuardi AW, et al. Cannabidiol can improve complex sleep-related behaviors associated with rapid eye movement sleep behavior disorder in Parkinson’s disease patients: a case series. J Clin Pharm Ther. 2014;39(5):564-566.

5. Lotan I, Treves TA, Roditi Y, Djaldetti R. Cannabis (medical cannabis) treatment for motor and non-motor symptoms of Parkinson’s disease: an open-label observational study. Clin Neuropharmacol. 2014;37(2):41-44.

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